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The disorder is caused by a defective or abnormally altered gene that causes one of the proteins responsible for the initial arrest of bleeding (called von Willebrand factor) to be low or not function properly

Once mixed, the solution is stable at 28C for 28 days, but every needle puncture introduces contamination risk, so using a vial within 21 days and minimizing punctures (one draw per dose, never re-injecting air) extends usable life

Below 0.1% the functional signal is essentially undetectable in published dose-response data

The non-solvent second phase is free from solvents for the polymer and active agent

In some embodiments, the ear is the outer ear